Convergent Synthesis of Dihydrobenzofurans via Urea Ligand-Enabled Heteroannulation of 2-Bromophenols with 1,3-Dienes

Article
ACS Catalysis / Vol. 13, Issue 10
Amanda M. Canfield, Kaitlyn E. Houghtling, Shauna M. Paradine

We disclose a palladium and urea ligand-mediatedheteroannulation of 2-bromophenols and 1,3-dienes. This methodaddresses synthetic challenges present in the palladium-catalyzedheteroannulation of bifunctional reagents and olefins by engaging adiverse scope of coupling partners under a unified set of reactionconditions. Our recently developed urea ligand platform outperformsphosphine ligands to generate the dihydrobenzofuran motif in aconvergent manner.

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